Dr Jerome Maller

 

Jerome Maller

Dr Jerome Maller is a Neuroscientist and Adjunct Associate Professor in the Therapeutic Brain Stimulation stream at MAPrc. His most recent fellowship was as an NHMRC Industry Career Development Fellow (CDF) with a focus on a specialised MRI technique referred to as Susceptibility Weighted Imaging (SWI) and its clinical relevance in the context of traumatic brain injury (TBI).  He previously completed a Centre for Excellence in Traumatic Brain Injury Research (CETBIR) Acute Care Fellowship focussing on blood-brain barrier permeability, and a Victorian Neurotrauma Initiative Research Fellowship using an MRI technique called Diffusion Tensor Imaging (DTI) to demonstrate that it can be predictive of the development of major depression after experiencing a TBI. His regular activities also involve other brain-related imaging and/or stimulation technologies (e.g. transcranial magnetic stimulation [TMS], electroencephalography [EEG], near infra-red [NIR], thermography [forward looking IR]). Dr Maller is involved in many local and international studies including the Monash University Bionic Eye study, the ANU’s PATH Through Life study, and the French ‘3-cities’ study. Dr Maller has over 100 peer-reviewed journal publications and has been involved in successfully obtaining over $4 million in grant funding. He is also an Adjunct Associate Professor at the Australian National University, and a MRI Clinical Science Specialist at General Electric Healthcare, specializing in prototype MRI.

Dr Maller has compiled the Handbook of Structural Brain MRI Analysis for those new to neuroimaging. It can be found here.

 

Selected publications
 

Callaghan F, Maller JJ, Welton T, Middione MJ, Shankaranaranayan A, Grieve SM. (2018). Toward personalized diffusion MRI in psychiatry: improved delineation of fibre bundles with the highest-ever angular resolution in vivo tractography. Translational Psychiatry 8(1):91-100.

 

Maller JJ, Broadhouse K, Rush AJ, Gordon E, Koslow S, Grieve SM. (2018). Increased hippocampal tail volume predicts depression status and remission to anti-depressant medications in major depression. Molecular Psychiatry 23(8):1737-44.

 

Grieve SM, Maller JJ. (2017). High-resolution diffusion imaging – ready to become more than just a research tool in psychiatry? Molecular Psychiatry 22(8):1082-4.

 

Maller JJ, Thomson RH, McQueen S, Elliott D, Fitzgerald PB. (2016). Factors to consider when applying transcranial magnetic stimulation of the dorsolateral prefrontal cortex when resting motor threshold is asymmetric: A case study. Bioelectromagnetics 37(2):130-5.

 

Maller JJ, Anderson R, Thomson RH, Rosenfeld JV, Daskalakis ZJ, Fitzgerald PB. (2015). Occipital bending (Yakovlevian torque) in bipolar depression. Psychiatry Research Neuroimaging 231(1):8-14.

 

Maller JJ. (2014). Neuroplasticity in normal and brain injured patients: Potential relevance of ear wiggling locus of control and cortical projections. Medical Hypotheses 83(6):838-843.

 

 

Maller JJ, Thomson RH, Pannek K, Bailey N, Lewis PM, Fitzgerald PB. (2014). Volumetrics relate to the development of depression after traumatic brain injury. Behavioural Brain Research S0166-4328(14):00350-7.

 

Maller JJ, Thomson RHS, Rosenfeld JV, Anderson R, Daskalakis ZJ, Fitzgerald PB. (2014). Occipital bending in depression. Brain 137(Pt 6):1830-7.

 

Maller JJ, Thomson RHS, Pannek K, Rose SE, Bailey N, Lewis PM, Fitzgerald PB. (2014). The (eigen)value of diffusion tensor imaging to investigate depression after traumatic brain injury. Human Brain Mapping 35(1):227-37.

 

Gurvich  C*, Maller JJ*, Lithgow B, Haghgooie S, Kulkarni J. (2013). Vestibular insights into cognition and psychiatry.Brain Research 1537:244-59. *Co-first authors.

 
Conditions/Disorders Investigated

Major depression disorder                                             

Bipolar disorder

Schizophrenia

Traumatic brain injury (TBI)

And a number of others, such as visual neglect, hydrocephalus, and pre-clinical dementia

Of course, I also research healthy people!

MRI Lab

We acquire and analyze a variety of MRI scans acquired in scanners ranging in magnetic strength (1.5T to 7T), including:

T1-weighted                                                              

T2-weighted/FLAIR

Diffusion Tensor Imaging (DTI)

Susceptibility Weighted Imaging (SWI)

MRS (MR Spectroscopy)

fMRI (Functional MRI)

TMS-EEG

I have been involved in TMS and EEG research, separately and combined, since 2006. Led by Prof Paul B Fitzgerald, we have produced a plethora of peer-reviewed publications and elucidated a number of significant findings.

We regularly utilise MRI technology to refine our clinical and research TMS and/or EEG techniques. For example, we have published papers directly related to the accuracy of TMS coil placement by utilising magnetic stereotaxic fields.

 

Thermography (Far length or Forward Looking IR)

I have been utilising FL-IR technology for a number of years in the context of psychiatry research. For example, we have found that eye temperature is lower in patients with major depression than in healthy people, a finding we anticipate of publishing shortly. Pic: http://www.health.vic.gov.au/healthvictoria/jul11/rscs_jul11/eye.jpg

The lab has begun to use FL-IR cameras for other purposes, such as visualising vasculature. We use mainly Testo 875-1 (8 to 12 micron) and Agema Thermovision 450 (2 to 5 micron), as well as highly-sensitive near infrared (NIR) cameras (specifically the Watec 902H Supreme).

Electrovestibulography

EVestG (Trade Mark) is a method of recording electrical signals from the vestibular system by inserting a probe in the ear canal. The recordings are taken while the person is being tilted in a chair to stimulate the vestibular system. The developers of this technology have claimed that it is able to accurately diagnose a range of mental and neurological disorders, including schizophrenia, depression, bipolar disorder and Alzheimer’s disease.