Current projects

1. TMS for depression

Aim

This study aims to compare the use of unilateral, bilateral, and sham transcranial magnetic stimulation (TMS) as a therapy for people with treatment-resistant depression.

Participants
People with treatment-resistant depression.

Project status

This project is currently under way. Approximately two-thirds of the target number of participants have completed their treatments.
 

 
2. TMS for depression following a mild to moderate Traumatic Brain Injury (TBI)
   
Aim
This study aims to compare the use of bilateral and sham TMS as a therapy for participants who have developed depression following a mild to moderate TBI.
 
Participants
People who have developed depression following a mild to moderate TBI.

Project status

This project is currently in progress. 
 

3. TMS for bipolar depression
   
Aim
This study aims to compare the use of bilateral and sham TMS as an alternative therapy for participants with bipolar depression.

Participants
People with bipolar depression.

Project status

This project is currently in progress.
 

4. Deep TMS for autism and Asperger’s disorder
   
Aim
This study aims to compare the use of prefrontal midline and sham deep TMS as an intervention for improving social functioning in autism spectrum disorders.

Project status

This project is currently in progress.
 

5. tDCS for depression
   
Aim
To evaluate transcranial direct current stimulation (tDCS) as a treatment for depression.

Methods

The study involves a comparison of active versus sham bilateral tDCS as an alternative therapy in the treatment of depression.

Project status

This project is currently in progress.
 

6. tDCS for schizophrenia
 
Aim
To evaluate transcranial direct current stimulation (tDCS) as a treatment for schizophrenia.

Methods

This study involves a comparison of active versus sham unilateral (left-sided) tDCS as an alternative therapy in the treatment of schizophrenia and schizoaffective disorder.

Project status

This project is currently in progress.
 

 
7. DBS for treatment resistant depression
 
Aim
To evaluate deep brain stimulation (DBS) in depression that has proved exteremely resistant to standard treatments.

Methods

This study involves patients who have depression that has proved extremely resistant to standard treatments.

Project status

This project is currently in progress.
 

 
 8. MST for treatment resistant depression   
   
Aim
To evaluate magnetic seizure therapy (MST) for patients with depression that has proved extremely resistant to standard treatments.

Methods

This study involves patients with depression that have proved extremely resistant to standard treatments.

Project status

This project is currently in progress
 

 

Other current projects

 
9. Childhood trauma, depression and hippocampal volume
This project investigates the relationship between childhood trauma, depression and hippocampal volume (a part of the brain).
 
 
10. Prefrontal cortical inhibition in depression and schizophrenia
 This project combines TMS and EEG to explore cortical inhibition (regulation of specific brain pathways) in depression and schizophrenia.
 

11. Brain changes depression following TBI

This project uses EEG and diffusion tensor imaging (DTI) to study white matter pathways in people with depression, some of whom have previously experienced a traumatic brain injury (TBI).

 
12. Cortical function in autism spectrum disorders (ASD)

This study uses several techniques: transcranial magnetic stimulation (TMS), electroencephalography (EEG) and functional magnetic resonance imaging  (fMRI) to explore the brain basis of autism spectrum disorders (ASD), and the relationship with clinical and neurobehavioural profiles.  

 
13. NIRS and prefrontal response to TMS

This project combines the techniques of near infrared spectroscopy (NIRS) and single/paired pulse transcranial magnetic stimulation (TMS) to examine the brain’s response to magnetic stimulation.

 
14. Electrophysiological correlates of major depression

This project uses electroencephalography (EEG) to examine aspects of brain activity and function , specifically alpha activity and hemispheric lateralisation, in women with depression.

 
15. A Transcranial Magnetic Stimulation study of cortical activity in HIV-1 Associated Neurocognitive Disorder.

This project aims to investigate the potential role of transcranial magnetic stimulation (TMS) in detecting early signs of neurocognitive (thinking) impairment in people with HIV infection. 

 

 

 MAPrc Monash Alfred Psychiatry Research Centre, Level 1, Old Baker Building, Alfred Hospital, Melbourne 3008

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