Dr Jerome Maller

 

Dr Jerome Maller is a Neuroscientist and Senior Research Fellow in the Brain Stimulation and Neuroimaging Lab at MAPrc. He is currently an NHMRC Industry Career Development Fellow (CDF) with a focus on a specialised MRI technique referred to as Susceptibility Weighted Imaging (SWI) and its clinical relevance in the context of traumatic brain injury (TBI).  He previously completed a Centre for Excellence in Traumatic Brain Injury Research (CETBIR) Acute Care Fellowship focussing on blood-brain barrier permeability, and a Victorian Neurotrauma Initiative Research Fellowship using an MRI technique called Diffusion Tensor Imaging (DTI) to demonstrate that it can be predictive of the development of major depression after experiencing a TBI. His regular activities also involve other brain-related imaging and/or stimulation technologies (e.g. transcranial magnetic stimulation [TMS], electroencephalography [EEG], near infra-red [NIR], thermography [forward looking IR]). Dr Maller is involved in many local and international studies including the Monash University Bionic Eye study, the ANU’s PATH Through Life study, and the French ‘3-cities’ study. Dr Maller has over 80 peer-reviewed journal publications and has been involved in successfully obtaining over $3.5 million in grant funding. He is also an Adjunct Associate Professor at the Australian National University.

Dr Maller has compiled the Handbook of Structural Brain MRI Analysis for those new to neuroimaging. It can be found here.

Selected publications
 
Maller JJ, Thaveenthiran P, Thomson RH, McQueen S, Fitzgerald PB. (2014). Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder Type I and II. Journal of Affective Disorders 168:118-27.

Maller JJ, Thomson RH, Pannek K, Bailey N, Lewis PM, Fitzgerald PB. (2014). Volumetrics relate to the development of depression after traumatic brain injury. Behavioural Brain Research S0166-4328(14):00350-7.

Maller JJ, Thomson RHS, Rosenfeld JV, Anderson R, Daskalakis ZJ, Fitzgerald PB. (2014). Occipital bending in depression. Brain 137(Pt 6):1830-7.

Maller JJ, Reglade-Meslin C. (2014). Longitudinal hippocampal and fornix changes after traumatic brain injury: Observations from traditional structural magnetic resonance imaging. Journal of Neurology and Neurophysiology 5(1):1-8.

Maller JJ, Thomson RHS, Pannek K, Rose SE, Bailey N, Lewis PM, Fitzgerald PB. (2014). The (eigen)value of diffusion tensor imaging to investigate depression after traumatic brain injury. Human Brain Mapping 35(1):227-37.

Gurvich  C*, Maller JJ*, Lithgow B, Haghgooie S, Kulkarni J. (2013). Vestibular insights into cognition and psychiatry. Brain Research 1537:244-59. *Co-first authors.

Maller JJ, Reglade-Meslin C, Thomson RHS, Daigle M, Barr MS, Daskalakis ZJ, Fitzgerald PB. (2013). Hippocampal sulcal cavities in depression and healthy individuals. Journal of Affective Disorders 150(3):785-89.

Fitzgerald PB, Hoy, KE, Herring SE, McQueen S, Peachey AVJ,  Segrave RA, Maller J, Hall P,  Daskalakis ZJ. (2012). A Double Blind Randomized Trial of Unilateral Left and Bilateral Prefrontal Cortex Transcranial Magnetic Stimulation in Treatment Resistant Major Depression. Journal of Affective Disorders 139(2):193-8.

Maller JJ, Daskalakis ZJ, Thomson RHS, Daigle M, Barr MS, Fitzgerald PB. (2012; Accepted June 2010). Hippocampal volumetrics in treatment-resistant depression and schizophrenia: The Devil's in de-tail. Hippocampus 22(1):9-16.

Maller JJ, Réglade-Meslin C, Chan P, Daskalakis ZJ, Thomson RH, Anstey KJ, Budge M, Sachdev P, Fitzgerald PB. (2011). Hippocampal sulcal cavities: prevalence, risk factors and relationship to memory impairment. Brain Research 1368:222-30.

Maller JJ, Thomson RH, Lewis PM, Rose SE, Pannek K, Fitzgerald PB. (2010) Traumatic brain injury, major depression, and diffusion tensor imaging: Making connections. Brain Research Reviews 64(1):214-30.
 
Conditions/Disorders Investigated

Major depression disorder                                             

Bipolar disorder

Schizophrenia

Traumatic brain injury (TBI)

And a number of others, such as visual neglect, hydrocephalus, and pre-clinical dementia

Of course, I also research healthy people!

MRI Lab

We acquire and analyze a variety of MRI scans acquired in scanners ranging in magnetic strength (1.5T to 7T), including:

T1-weighted                                                              

T2-weighted/FLAIR

Diffusion Tensor Imaging (DTI)

Susceptibility Weighted Imaging (SWI)

MRS (MR Spectroscopy)

fMRI (Functional MRI)

TMS-EEG

I have been involved in TMS and EEG research, separately and combined, since 2006. Led by Prof Paul B Fitzgerald, we have produced a plethora of peer-reviewed publications and elucidated a number of significant findings.

We regularly utilise MRI technology to refine our clinical and research TMS and/or EEG techniques. For example, we have published papers directly related to the accuracy of TMS coil placement by utilising magnetic stereotaxic fields.

 

Thermography (Far length or Forward Looking IR)

I have been utilising FL-IR technology for a number of years in the context of psychiatry research. For example, we have found that eye temperature is lower in patients with major depression than in healthy people, a finding we anticipate of publishing shortly. Pic: http://www.health.vic.gov.au/healthvictoria/jul11/rscs_jul11/eye.jpg

The lab has begun to use FL-IR cameras for other purposes, such as visualising vasculature. We use mainly Testo 875-1 (8 to 12 micron) and Agema Thermovision 450 (2 to 5 micron), as well as highly-sensitive near infrared (NIR) cameras (specifically the Watec 902H Supreme).

Electrovestibulography

EVestG (Trade Mark) is a method of recording electrical signals from the vestibular system by inserting a probe in the ear canal. The recordings are taken while the person is being tilted in a chair to stimulate the vestibular system. The developers of this technology have claimed that it is able to accurately diagnose a range of mental and neurological disorders, including schizophrenia, depression, bipolar disorder and Alzheimer’s disease.

 If you are interested in working with Jerome on research studies, please contact him on: Jerome.maller@monash.edu

            

 

                     

We are offering a PhD position at the Monash Alfred Psychiatry Research Centre (MAPrc) in the fields of neuropsychiatry and neurophysiology. The PhD project will encompass a number of domains relating to mild traumatic brain injury (mTBI) and the vestibular system. The candidate will be responsible for MRI brain scanning rats in the Monash Biomedical Imaging 9.4Tesla MRI scanner using advanced techniques such as resting state functional MRI and diffusion tensor imaging. The data is then to be analysed in order to establish the pathways between the vestibular system and other brain regions in both healthy and mTBI rats. The successful candidate will also be involved in behavioural assessment of these small animals. The successful candidate will apply for the standard APA scholarship which will then be supplemented by an additional AUD$10,000 per year scholarship from the industry partner.

The benefits to ND from investing in this research is to build clinical/biomedical evidence that EVestG works as it is believed to work when measuring subjects suffering and recovering repeated mTBI.

If you are interested in this opportunity, please contact Dr Jerome Maller at jerome.maller@monash.edu or Associate Professor Ramesh Rajan at Ramesh.Rajan@monash.edu

 

 MAPrc Monash Alfred Psychiatry Research Centre, Level 4, 607 St Kilda Road, Melbourne 3004

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