Double-Blind randomised investigation of Tibolone as an adjunct to standard antidepressant treatment for relapsed and persistent depression in peri- and post-menopausal women 

Aim: To examine the efficacy of a tissue-selective hormone treatment for menopausal depression.

Participants: Women between the ages of 45 and 65 years of age who have been diagnosed with Major Depressive Disorder (Major Depression) or are currently experiencing depressive symptoms that have relapsed during peri or post menopause.  

Method: This is 12 week randomised controlled trial where participants will be randomly allocated to one of two study groups where they will receive either; 1) tibolone or 2) placebo daily. Researchers from the Women's Mental Health team will speak with participants fortnightly (over the phone) then monthly throughout the treatment trial to monitor how they are progressing.

Project status: Currently recruiting

Researchers: Professor Jayashri Kulkarni, Ms Emmy Gavrilidis, Dr Natalie Thomas, Dr Caroline Gurvich

Study Coordinator: Emmy Gavrilidis

Contact information: For more information, please contact Emmy Gavrilidis on emmy.gavrilidis@monash.edu or 9076 6913

 MAPrc Monash Alfred Psychiatry Research Centre, Level 4, 607 St Kilda Road, Melbourne 3004

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